1、个人简介

陈洪丽，中国医学科学院生物医学工程研究所副教授。天津医科大学生物医学工程专业学士和硕士学位，北京协和医学院生物医学工程专业博士学位，天津大学博士后，清华大学-IDG/麦戈文脑科学研究院访问学者，天津工业大学副教授（2016-2024）。天津市“131”第三层次人才，天津市“青年后备人才培养计划”人选。担任天津市医学会激光医学分会常委，中国光学学会第四届生物医学光子学青年委员，天津市激光技术学会理事，中华医学会激光医学分会委员，天津市健康教育协会眼健康教育分会委员。

研究方向为光生物调节与神经调控、可穿戴光学诊疗设备研发。聚焦神经系统基本科学问题，开展光调控的关键技术及机制研究。重点围绕神经损伤和神经调控，运用分子与细胞生物学、神经生物学等方法，采用先进光学技术开展干细胞调控、神经损伤修复及相关病变研究，以此为依据，推动诊疗设备研发和临床应用转化。主要研究对象包括阿尔茨海默病、抑郁症、睡眠障碍和脊髓损伤等，旨在以不同疾病的发病机制为依据，实现对光学参数、作用通路和作用靶点的精准研究，构建精准光生物学的创新链条，为通过光生物学方法解决重大疑难问题提供科学依据和技术支撑。主持国家自然科学基金1项，主持省部级项目4项，主持天津市教委项目1项，参与科技部重点研发项目2项。在国内外期刊发表论文30余篇，申请专利16项，专利成果转化3项，开发样机6台。

2、代表性成果

[1] Hongli Chen*, Na Li, Yuanhao Cai, Chunyan Ma, YutongYe, Xinyu Shi, Jun Guo, Zhibo Han, Yi Liu,  Xunbin Wei*. Exosomes in neurodegenerative diseases: therapeutic potential and modification methods. Neural Regeneration Research. 2026, 21(2):478-490. (中科院二区，IF=6.7)

[2] Chunyan Ma, Yutong Ye, Xinyu Shi, Na Li, Zhiming Mu, Tao Tan, Huijuan Yin, Jianwu Dai, Yi Liu, Hongli Chen*. Photobiomodulation mitigates blood-brain barrier disruption in APP/PS1 mouse model of Alzheimer’s disease by activating the AMPK pathway. Alzheimers Research & Therapy. 2025, 17: 141. (中科院一区Top，IF=7.6)

[3] Hongli Chen*, Na Li, Na Liu, Hongyu Zhu, Chunyan Ma, Yutong Ye, Xinyu Shi, Guoshuai Luo, Xiaoxi Dong, Tao Tan, Xunbin Wei*, Huijuan Yin*. Photobiomodulation modulates mitochondrial energy metabolism and ameliorates neurological damage in an APP/PS1 mouse model of Alzheimer’s disease. Alzheimers Research & Therapy. 2025, 17: 72. (中科院一区Top，IF=7.6)

[4] Yutong Ye, Yongli Ji, Chunyan Ma, Jun Guo, Zhongxiu Chen, Yi Liu*, Hongli Chen*. Niobium carbide MXenzyme for targeting disaggregation of human insulin fibrils and anti-inflammation. International Journal of Biological Macromolecules. 2025, 308: 142542.  (中科院一区Top，IF=8.5)

[5] Na Li, Na Liu, Yutong Ye, Haoxin Shi, Jia Shi, Guoshuai Luo, Jun Guo, Yi Liu, Hongli Chen*. Photobiomodulation ameliorates neuronal damage in an amyloid-beta induced rat model. IEEE Journal of Selected Topics in Quantum Electronics. 2025, 31(4): 1-9.  (中科院二区，IF=5.1)

[6] Chunyan Ma, Yutong Ye, Xinyu Shi, Na Li, Yufei Chen, Xiafei Shi, Hongli Chen*. Photobiomodulation promotes osteogenic differentiation of mesenchymal stem cells and increases P-Akt levels in vitro. Scientific Reports. 2025, 15, 17844. (中科院三区，IF=3.9)

[7] Chunyan Ma, Hongyu Zhu, Yuanhao Cai, Na Li, Zhibo Han, Huancheng Wu, Hongli Chen*. Photobiomodulation combined with human umbilical cord mesenchymal stem cells modulates the polarization of microglia. Journal of Biophotonics. 2025, 18 (4). (中科院三区，IF=2.3)

[8] Na Li, Xuechun Li, Zhongdi Jiang, Xiafei Shi, Huancheng Wu, Yi Liu, Huijuan Yin, Hongli Chen*. Phototherapy and optogenetic stimulation improve cognitive function in sleep-deprived mice. Journal of Innovative Optical Health Sciences. 2025, 18(2): 2550001. (中科院三区，IF=2.2)

[9] Hongli Chen, Xinyu Shi, Na Liu, Zhongdi Jiang, Chunyan Ma, Guoshuai Luo, Shuang Liu*, Xunbin Wei*, Yi Liu*, Dong Ming. Photobiomodulation therapy mitigates depressive-like behaviors by remodeling synaptic links and mitochondrial function. Journal of Photochemistry and Photobiology B: Biology, 2024, 258, 112998.  (中科院一区，IF=3.9)

[10] Pai Liu, Tianyue Yang, Yaning Li, Jun Guo, Shulan Li, Hongli Chen*, Yi Liu*. Nanomaterial-based sonosensitizers: from exemplary design towards purposeful improvement. Materials Chemistry Frontiers. 2023, 7, 985-1003. (中科院一区，IF=8.9)

[11] Hongli Chen, Yuanhao Cai, Shujie Sun, Zhenhua Pan, Zhibo Han, Pai Liu*, Yi Liu*. Repair effect of photobiomodulation combined with human umbilical cord mesenchymal stem cells on rats with acute lung injury. Journal of Photochemistry and Photobiology B: Biology. 2022(234):112541. (中科院一区, IF=6.813)

[12] Hongli Chen, Yufei Chen, Yunhao Wang, Tingting Li, Pai Liu, Zhibo Han, Yue Sun, Yi Liu*. Study on the osteogenic differentiation of hUCMSCs in silk fibroin/polycaprolactone membrane under the intervention of photobiomodulation. IEEE Journal of Selected Topics in Quantum Electronics. 2022.29(4):1-8. (中科院二区, IF=4.653)

[13] 陈洪丽, 高静静, 姜忠迪, 王仲朋, 陈龙*, 明东. 光疗对睡眠剥夺小鼠学习记忆以及 BDNF-TrkB信号通路的影响. 中国激光, 2022, 49(5): 0507011. (EI期刊)

[14] 陈洪丽, 高静静, 杨佳佳, 姜忠迪, 陈瑞娟, 刘爽*, 明东. 光疗及光照剂量对抑郁症的作用研究进展.生物化学与生物物理进展. 2021, 48(12):1422-1428.

[15] Hongli Chen, Shujie Sun, Zhenhua Pan, Mengru Tu, Jia Shi, Hua Bai*, Zhibo Han, Jianquan Yao. Effects of Photobiomodulation on High Glucose Induced Oxidative Stress in Human Embryonic Skin Fibroblasts. IEEE Journal of Selected Topics in Quantum Electronics. 2021, 27(4): 1-9. (中科院二区, IF=4.653)